Application

1,4-Dithiane-2,5-diol was used in the synthesis of:substituted tetrahydrothiophene derivatives2-amino-3-(arylsulfonyl)thiophenes, potential antiviral and antitumor agents

General description

1,4-Dithiane-2,5-diol undergoes bifunctional squaramide catalyzed sulfa-Michael/aldol cascade reaction with chalcones to afford trisubstituted tetrahydrothiophenes. It participates in diastereoselective [3+3] cycloaddition with azomethine imines catalyzed by 1,4-diazabicyclo[2.2.2]octane. It is a mercaptoacetaldehyde dimer and an efficient synthon for incorporating a thiol group to in situ generated nitroalkenes.

Packaging

50, 250 g in glass bottle