Zaprinast, solid

Code: Z0878-25MG D2-231

Application

Zaprinast has been used to determine its inhibitory effect on the meiosis of oocytes by germinal vesicle breakdown (GVBD) assay and to test the inhibitory effect...


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€127.33 25MG
€156.62 inc. VAT
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Application

Zaprinast has been used to determine its inhibitory effect on the meiosis of oocytes by germinal vesicle breakdown (GVBD) assay and to test the inhibitory effect of it on the retinal cells by immunohistochemistry.

Biochem/physiol Actions

Selective inhibitor of cGMP-specific phosphodiesterases V and VI (PDE5/6) and an agonist at the G protein-coupled receptor 35 (GPR35).

Zaprinast insubstantially inhibits phosphodiesterase 10 and 11 (PDE10 and PDE11). It also exhibits vasodilating effects.

Packaging

25, 100 mg in poly bottle

colorwhite
formsolid
Gene Informationhuman ... PDE2A(5138), PDE4A(5141), PDE4B(5142), PDE4D(5144)
InChI keyREZGGXNDEMKIQB-UHFFFAOYSA-N
InChI1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
Quality Level200
SMILES stringCCCOc1ccccc1C2=NC(=O)c3nn[nH]c3N2
solubilityDMSO: 10 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL, H2O: insoluble
Cas Number37762-06-4
This product has met the following criteria to qualify for the following awards:



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