Application

Catalyst for: Synthesis of primary amides Direct dehydrative phosphonium cross coupling Direct arylation Pyrrolidide formation by phosphonium salt coupling reagents

It can be used as a coupling reagent:For Suzuki–Miyaura cross-coupling of phenols and arylboronic acids to synthesize biaryls and heterobiaryls.To functionalize pyrimidines (synthesized from 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via the Kappe dehydrogenation) by using various nucleophiles.To synthesize formamidines by coupling with various primary amines and N,N-diisopropylethylamine.It can also be used as an activating reagent:For the activation of C-OH bond in tautomerizable heterocycles to form the phosphonium salt which aids the Sonogashira coupling of heterocycles with various alkynes.For the one–pot activation of C-O bond in phenols and further coupling reaction with phosphine oxide or phosphite to form C-P bonds.

Legal Information

PyBroP is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Reactive peptide coupling reagent suitable for α,α-dialkyl amino acids; Synthesis of depsipeptides

Packaging

5, 25 g in poly bottle

1 g in poly tube