Monastrol, >=98% (HPLC), solid

Application

Monastrol has been used:to treat MDA-MB-231 cells as a non-microtubule-targeting agentas a antineoplastic agent, to treat mouse myeloma cell line SP 2/0, to induce apoptosis and to elucidate the role of metabotropic glutamate receptor 3 (Grm3) in apoptosisas an inhibitor of pteridine reductase in GFP-transfected promastigotes infected macrophages for flow cytometer-based growth inhibition assay and to evaluate anti-leishmanial activity of Leishmania donovani hamster model in vivo

Biochem/physiol Actions

Monastrol is a potent, cell-permeant inhibitor of mitosis. Monastrol arrested cells are characterized by monopolar spindles. This phenotype is induced through specific disruption of mitotic molecular motor kinesin Eg5 with IC₅₀ at 14 µM. No effect on other motor proteins and tubulin.

Features and Benefits

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Packaging

Packaged under inert gas.

1, 5 mg in glass bottle