(-)-Gallocatechin gallate, from green tea, >=98% (HPLC)

Application

(−)-Gallocatechin gallate has been used:to perform the tannase activity assay of the recombinant Lactobacillus plantarum tannase enzymeto study its inhibitory effects on HIV-1 integrase activity to study its regulatory mechanism on cholesterol metabolism in rat liverto analyze its effect as a polyphenol on human spermatozoa and their application in assisted reproductive technologyto study the interference in stress protective activity of cellular prion protein (PrP^C) and the formation of scrapie prion protein (PrP^Sc)

Biochem/physiol Actions

Tea catechins like (−)-Gallocatechin gallate are known to have antiviral, antioxidative, antimutagenic and antiobesity activities. It exhibits human immunodeficiency virus-1 (HIV-1) integrase inhibitory activity by disturbing the interaction between the human immunodeficiency virus-1 (HIV-1) integrase and virus DNA. GCG also shows impeding effect on the release of vero toxins (VTs) by enterohemorrhagic Escherichia coli. It displays an inhibitory effect on cholesterol absorption and is reported to be more effective than tea catechins in lowering plasma cholesterol, thus preventing atherosclerosis.

General description

(−)-Gallocatechin gallate is a polyphenolic compound having a galloyl moiety. It is an epimerized form of epigallocatechin gallate, which is common tea catechin. Epimerization of tea catechins is common upon heat treatment or pasteurization process.

Packaging

5 mg in glass bottle