ANTI-C9ORF72, ANTIBODY PRODUCED IN

Code: SAB4200623-100UL D2-231

Application

Anti-C9orf72 antibody produced in rabbit may be used in: immunoblotting immunocytochemistry immunohistochemistry

Biochem/physiol Actions

read more

Your Price
€532.00 EACH
€654.36 inc. VAT

Application

Anti-C9orf72 antibody produced in rabbit may be used in: immunoblotting immunocytochemistry immunohistochemistry

Biochem/physiol Actions

C9orf72 (chromosome 9 open reading frame 72) maintains a physical interaction with Rab proteins during autophagy, cellular trafficking and protein degradation. The cellular activities of the protein are not well defined. It has been reported that mutations of C9orf72 gene are associated with amyotrophic lateral sclerosis (ALS) with degeneration of upper and lower motor neurons in the brain, brainstem and spinal cord, leading to progressive paralysis and frontotemporal dementia.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Chromosome 9 open reading frame 72 (C9orf72) gene is mapped to human chromosome 9p21.

C9orf72 (chromosome 9 open reading frame 72) is a DENN domain containing protein. It is expressed in neuronal cell lines. It has been reported that C9orf72 colocalizes with Rab proteins, which indicates its role in autophagy and endocytic transport pathways.

Immunogen

synthetic peptide corresponding to the N-terminal region of human C9orf72

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Specificity

Anti-C9orf72 recognizes human C9orf72.

Storage and Stability

For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
concentration~1 mg/mL
formbuffered aqueous solution
Gene Informationhuman ... C9orf72(203228)
mol wt~55 kDa
Quality Level200
shipped indry ice
species reactivityhuman
storage temp.−20°C
technique(s)immunoblotting: 0.3-0.6 µg/mL using whole extracts of T98G cells, immunohistochemistry: 10 µg/mL using heat-retrieved formalin-fixed, paraffin-embedded human colon sections, immunocytochemistry: 4-6 µg/mL using SH-SY-5Y cells
UniProt accession no.Q96LT7
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN


GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.