Biochem/physiol Actions

IL-37 (interleukin 37) acts as a suppressor for innate immunity and acquired immunity. IL-37 participates in the immunosuppressive property of human CD4⁺CD25⁺ regulatory T cells. It represses the synthesis of several pro-inflammatory cytokines like IL-1α, IL-1β, IL-6, IL-12, granulocyte colony-stimulating factor (G-SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and TNF-α (tumor necrosis factor alpha). It plays an important role in adaptive immunity.

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General description

IL-37 (interleukin 37) is an anti-inflammatory cytokine and is also termed as IL-1 family member 7 (IL-1F7). IL-37 belongs to the IL-1 cytokine family. This protein is expressed in blood monocytes, endothelial cells, adipocytes and epithelial cells. IL-37 is located on human chromosome 2q12.

Immunogen

Antibody was raised against a 17 amino acid peptide near the amino terminus of human IL-37.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500952.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.