Anti-PGC1A antibody produced in goat, affinity isolated antibody, buffered aqueous solution

Code: SAB2500781-100UG D2-231

Application

Anti-PGC1A antibody produced in goat has been used in Western blotting.

Biochem/physiol Actions

Peroxisome proliferator-activated rec...


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€566.00 100UG
€696.18 inc. VAT

Application

Anti-PGC1A antibody produced in goat has been used in Western blotting.

Biochem/physiol Actions

Peroxisome proliferator-activated receptor γ (PPARG) coactivator 1 α (PPARGC1A) modulates the expression of mitochondrial oxidative phosphorylation (OXPHOS) genes and endogenous antioxidants. Variation in the gene expression leads to Huntington′s disease (HD) and Type 2 diabetes. PGC-1α functions as a ‘;molecular switch’; in genetic pathways involved in maintaining glucose homeostasis in liver and muscle, β cell insulin secretion and mitochondrial biogenesis. Addition to this, PGC-1α has a crucial role to play in adaptive thermogenesis, skeletal muscle fiber type switching and heart development. PGC-1α reduces or improves muscle dystrophy by stimulating various molecular pathways; therefore, increase in the concentration and activity of PGC-1 is considered to be a potential method for Duchene muscular dystrophy (DMD) treatment.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Peroxisome proliferator-activated receptor γ (PPARG) coactivator 1 α (PPARGC1A) encodes the 798 amino acid protein, PGC-1α. It is a multifunctional transcriptional protein, which belongs to the family of transcription co-activators involved in the regulation of cellular energy metabolism. PGC-1α is abundantly expressed in several human tissues that are active in oxidative metabolism, including heart, skeletal muscle, and the fasted liver. The gene encoding this protein is localized on human chromosome 4p15.1-2.

Immunogen

Peptide with sequence C-DGLFDDSEDESDK from the internal region of the protein sequence according to NP_037393.1.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcegoat
clonepolyclonal
conjugateunconjugated
formbuffered aqueous solution
Gene Informationhuman ... PPARGC1A(10891)
Quality Level100
shipped indry ice
species reactivitymouse, canine, rat, human
storage temp.−20°C
technique(s)indirect ELISA: suitable, western blot: suitable
UniProt accession no.Q9UBK2
This product has met the following criteria: