Biochem/physiol Actions

Myosin 1A (MYO1A) is a actin based motor protein, that exerts mechanical activity in the microvilli. Mutations in MYO1A are linked to autosomal dominant nonsyndromic deafness (NSD) in humans.

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General description

Myosin 1A (MYO1A) also known as Brush border myosin I (BBMI) belongs to the myosin superfamily. All members of the myosin I family possess three structural domains: a catalytic head domain that binds ATP and actin, a tail domain for its subcellular localization and a junction or neck domain. Myo1A is a membrane protein, expressed in intestinal tract and inner ear. In human chromosome, the gene MYO1A is localized on 12q13.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.