Anti-CD11c (human); PE-Cy7; clone 3.9

Code: MABF369 D2-231

Application

This Mouse Monoclonal Antibody Anti-CD11c (human), PE-Cy7, clone 3.9, Cat. No. MABF369 is validated for use in IP, IF, FC for the detection of CD11c.


read more

Your Price
€315.00 EACH
€387.45 inc. VAT

Application

This Mouse Monoclonal Antibody Anti-CD11c (human), PE-Cy7, clone 3.9, Cat. No. MABF369 is validated for use in IP, IF, FC for the detection of CD11c.

General description

The 3.9 antibody reacts with human CD11c, also known as integrin alpha X. This 150 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha X (CD11c) assembles with Integrin beta-2 (CD18) into a receptor known as CR4 which can bind and induce signaling through ICAMs and VCAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The 3.9 antibody is widely used as a marker for CD11c expression on dendritic cells (DC), often in parallel with markers for CD11b, for identification of developmental stages and mature subsets of this cell type. CD11c is prominently expressed on tissue macrophages, and is also detected on activated neutrophils, granulocytes, some types of activated T cells and intestinal intraepithelial lymphocytes (IEL). The antibody is reported to be cross-reactive with Baboon, Chimpanzee, Cynomolgus and Rhesus CD11c.

antibody formpurified antibody
antibody product typeprimary antibodies
biological sourcemouse
clone3.9, monoclonal
conjugatePE-Cy7
Gene Informationhuman ... ITGAX(3687)
isotypeIgG1κ
packagingpkg of 5 µL (1 µg/test)
Quality Level100
shipped inwet ice
species reactivityhuman
technique(s)flow cytometry: suitable, immunoprecipitation (IP): suitable, immunofluorescence: suitable
UniProt accession no.P20702
This product has met the following criteria to qualify for the following awards:



PROCEED TO CHECKOUT

HAVE AN ACCOUNT? LOGIN


GUEST CHECKOUT

Proceed as a guest. You will have the option to register to access exclusive pricing and stock availability features after checkout.