Application

Monoclonal Anti-Cul7 antibody produced in mouse is suitable for immunoprecipitation and western blotting at a concentration of 0.5-1µg/mL using 3T3 total cel extract.

Biochem/physiol Actions

Cullin-7 (cul7) is a protein encoded by the CUL7 gene in humans. It is also referred as 3M1, KIAA0076 and dJ20C7.5. Mutation in CUL7 gene is majorly responsible for 3M syndrome (is a rare autosomal recessive disorder). CUL7 acts as a novel gene potentially involved in liver carcinogenesis associated with metabolic syndrome (MS) and its amplification may influence cell proliferation.

CUL7 functions to promote cell growth through and antagonizes the function of p53.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Monoclonal Anti-Cul7 (mouse IgG2b isotype) is derived from the hybridoma Ab38 produced by the fusion of mouse myeloma cells (P3X63Ag8.653) and splenocytes from BALB/c mice immunized with mouse Cul7. CUL7 is expressed in all tissues and cell lines except testis and small intestine.

Immunogen

mouse Cul7.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.