Anti-HEY1

Code: AV32512-100UL D2-231

Application

Rabbit polyclonal anti-HEY1/HESR1 antibody is used to tag Hairy/enhancer-of-split related with YRPW motif 1 for detection and quantitation by immunocytochemical a...


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€734.00 100UL
€902.82 inc. VAT

Application

Rabbit polyclonal anti-HEY1/HESR1 antibody is used to tag Hairy/enhancer-of-split related with YRPW motif 1 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of Hairy/enhancer-of-split related with YRPW motif 1 in cardiovascular, skeletal muscle, osteoblast, osteoclast, chondrocyte and neural development.

Biochem/physiol Actions

Hairy/enhancer of split-related proteins, such as HEY1, are basic helix-loop-helix (bHLH) transcription factors implicated in cell fate decision and boundary formation. HEY genes are direct transcriptional targets of the Notch signaling pathways in Drosophila and vertebrates.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Hairy/enhancer-of-split related with YRPW motif 1 (HEY1, HESR1, HERP2, HRT1, CHF2), a basic helix-loop-helix (bHLH)-type transcription factor/repressor, is a downstream effector of Notch and c-Jun signaling. HEY1/HESR1 is involved in the regulation of cardiovascular, skeletal muscle, osteoblast, osteoclast, chondrocyte and neural development. HEY1/HESR1 is a repressor of myoblast differentiation/myogenesis and human dopamine transporter (DAT1) gene expression.

Immunogen

Synthetic peptide directed towards the C-terminal region of Human HEY1

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: PQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSFGPVLPVVTS

Specificity

Rabbit polyclonal anti-HEY1/HESR1 antibody reacts with human, mouse, rat, bovine, and canine Hairy/enhancer-of-split related with YRPW motif 1 transcription factors.

antibody formIgG fraction of antiserum
antibody product typeprimary antibodies
clonepolyclonal
concentration0.5 mg - 1 mg/mL
formbuffered aqueous solution
Gene Informationhuman ... HEY1(23462)
mol wt32 kDa
NCBI accession no.NP_001035798
Quality Level100
shipped inwet ice
species reactivityhuman
storage temp.−20°C
technique(s)western blot: suitable, immunohistochemistry: suitable
UniProt accession no.Q9Y5J3
This product has met the following criteria to qualify for the following awards:



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