Application

Anti- CCND3 antibody produced in rabbit is suitable for western blotting at a concentration of 0.5 µg/ml. For immunohistochemistry of paraffin-embedded tissue sections, a concentration of 4-8 µg/ml is suitable.

Biochem/physiol Actions

Cyclin D3 is a D-type cyclin that is critical for entry of mitotic cells into G1/S phase, cell differentiation, apoptosis and activation of transcription factors.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Cyclins are key regulatory proteins that control cell cycle progression by phosphorylating cyclin-dependent kinases.

Immunogen

Synthetic peptide directed towards the C terminal region of human CCND3

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: CQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL