Application

Suitable as a blocking agent using corresponding antibodies.

Biochem/physiol Actions

CHRM1 is activated by acetylcholine and it regulates multitude of physiological processes of the central and peripheral nervous system. It is also associated with learning, cognition and memory. CHRM1 is allosterically regulated and is a prime target for drug design in disorders of central nervous system. CHRM1 receptor modulation improves cognitive function. Elevated levels of CHRM1- acetylcholine complex is observed in patients with Alzheimer′s disease. Single polynucleotide polymorphisms in CHRM1 is observed in patients with schizophrenia. Mutations in the CHRM1 gene locus is associated with facial impairment and developmental delay.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Recombinant protein fragment of Human CHRM1 with N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G) fusion tag. Cholinergic receptor, muscarinic 1 (CHRM1) is also known as muscarinic acetylcholine receptor M1 (mAChRs). It encoded by gene CHRM1 located on human chromosome 11q12.3. Cholinergic receptor, muscarinic 1 (CHRM1) belongs to G protein-coupled receptors and comprises of 5 subtypes: M1 to M5.

Legal Information

Prestige Antigens is a trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antibody HPA014101.

Physical form

Solution in 1 M urea-PBS, pH 7.4

Preparation Note

The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.