Analysis Note

ControlHuman skeletal muscle tissue lysate.

Application

This Anti-MFAP-5 (MAGP2) Antibody is validated for use in WB for the detection of MFAP-5 (MAGP2).

Research CategoryCell Structure

Research Sub CategoryGlycobiologyAdhesion (CAMs)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Microfibril-associated protein 2 (MAGP-2), also known as microfibrillar associated protein 5 (MFAP-5), is a multifunctional secreted protein that acts as a promoter of tumor cell survival and angiogenesis. Through alphaVbeta3 integrin-mediated signaling, it is suggested that MAGP2 may provide a potential mechanistic link between MAGP2 and angiogenesis, as well as patient survival. Based on a high level of homology between MAGP (MFAP-2) and MAGP-2, both proteins are shown to bind to and activate Notch-1, as well as mediate the subsequent release of the Notch-1 extracellular domain.

Immunogen

KLH-conjugated linear peptide corresponding to human MFAP-5 (MAGP-2).

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blot in human skeletal muscle tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected MFAP-5 (MAGP-2) in skeletal muscle tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~19 kDa observed