Anti-ARMS2

Analysis Note

ControlHuman placenta tissue lysate

Application

This Anti-ARMS2 Antibody is validated for use in Western Blotting for the detection of ARMS2.

Research Sub CategoryNeurodegenerative Diseases

Research CategoryNeuroscience

Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in ARPE-19 cells. (Pericak-Vance, M., et al. (2009). Invest Ophthalmol Vis Sci. 50(7): 3084–3090.)

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Age-related maculopathy susceptibility protein 2 (ARMS2) is highly expressed in the human placenta and retina. The biological function of ARMS2 has not been fully characterized. However, previous studies have linked mutations in the ARMS2 and HtrA1 genes, located on chromosome 10q26, to the occurrence of age-related macular degeneration type 8, a condition of irreversible vision loss in the elderly.

Immunogen

KLH-conjugated linear peptide corresponding to human ARMS2.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified

Purified rabbit polyclonal in PBS containing 0.1% azide.

Quality

Evaluated by Western Blot in human placenta tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected ARMS2 on 10 µg of human placenta tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~12 kDa observed. An uncharacterized band appears at ~60 kDa in some lysates.