JAGGED-2 (HUMAN): FC (HUMAN)

General description

Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.

Physical form

Lyophilized. Contains PBS + 0.02 % CHAPS.

Reconstitution

Reconstitute with 100µl sterile water.

Sequence

Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.