RIVAROXABAN

Code: SML2844-5MG D2-231

Biochem/physiol Actions

Rivaroxaban is an orally active, active site-targeting, highly potent and selective factor Xa (FXa) inhibitor (IC50 = 0.7 nM; no activity a...


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Biochem/physiol Actions

Rivaroxaban is an orally active, active site-targeting, highly potent and selective factor Xa (FXa) inhibitor (IC50 = 0.7 nM; no activity against thrombin, trypsin, plasmin, FVIIa, FIXa, FXIa, urokinase, or activated protein C up to 20 µM) with good anticoagulant activity in vitro (dose for doubling fibrin formation time = 230/300 nM in human/rat plasma) and antithrombotic efficacy in vivo (ED50 = 1 mg/kg i.v. or 5 mg/kg p.o. by rat arteriovenous shunt model).

assay≥98% (HPLC)
colorwhite to beige
formpowder
optical activity[α]/D -34 to -44, c = 0.3 in DMSO
Quality Level100
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number366789-02-8
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