BDT001

Code: SML2639-25MG D2-231

Biochem/physiol Actions

BDT001 is a selective negative allosteric modulator of Flt-3 receptor tyrosine kinase. It showed minimal binding to 25 diverse RTKs and 49 intracellul...


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Biochem/physiol Actions

BDT001 is a selective negative allosteric modulator of Flt-3 receptor tyrosine kinase. It showed minimal binding to 25 diverse RTKs and 49 intracellular kinases. In primary cultures of adult DRG neurons, BDT001 reversed the potentiation of capsaicin-induced TRPV1 activation by FL, with a maximal effect at 1 µM. In a mouse study BDT001 alleviated nerve injury-induced peripheral neuropathic pain but had no effect on nociception in non-injured animals.

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringOC1=CC=C(C=C1NC(C2=CC=CC(S(N3CCCCC3)(=O)=O)=C2)=O)Cl
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
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