JH-II-127

Code: SML2569-25MG D2-231

Biochem/physiol Actions

JH-II-127 is an orally available, brain penetrant, potent and selective inhibitor of both wild-type and G2019S mutant Leucine-rich repeat kinase 2 (LR...


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€364.40 25MG
€448.21 inc. VAT
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Biochem/physiol Actions

JH-II-127 is an orally available, brain penetrant, potent and selective inhibitor of both wild-type and G2019S mutant Leucine-rich repeat kinase 2 (LRRK2). JH-II-127 inhibits phosphorylation of the Ser910 and Ser935 of both wild-type and G2019S mutant LRRK2. It causes complete inhibition of LRRK2 in mouse brain at 100 mg/kg.

assay≥98% (HPLC)
colorwhite to beige
formpowder
solubilityDMSO: 2 mg/mL, clear
storage temp.−20°C
Cas Number1700693-08-8
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