KL-2

Code: SML2538-5MG D2-231

Biochem/physiol Actions

KL-2 is a disruptor of the super elongation complex (SEC). KL-1 blocks the interactions of positive transcription elongation factorb (P-TEFb) and the ...


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Biochem/physiol Actions

KL-2 is a disruptor of the super elongation complex (SEC). KL-1 blocks the interactions of positive transcription elongation factorb (P-TEFb) and the SEC-scaffolding protein AFF4 resulting in decreased Polymerase II (Pol II) activity and production of Pol II-transcribed genes. KL-2 was shown to cause downregulation of heat shock genes, and was non-toxic and active in an animal model of cancer.

Disruptor of SEC (super elongation complex)

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringCC1=CC=C(Cl)C=C1NC(/C(O)=C/C(C2=CC=C(F)C=C2)=O)=O
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number900308-51-2
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