SENICAPOC

Code: SML2500-25MG D2-231

Biochem/physiol Actions

Senicapoc (ICA-17043) is an inhibitor of the calcium-activated K+ channel KCa3.1, also known as the Gardos channel, which plays a role in K...


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€377.90 25MG
€464.82 inc. VAT

Biochem/physiol Actions

Senicapoc (ICA-17043) is an inhibitor of the calcium-activated K+ channel KCa3.1, also known as the Gardos channel, which plays a role in K+ loss and dehydration of sickled red blood cells. Senicapoc blocks calcium-induced rubidium flux in human RBCs with and IC50 of 11 nM and prevents RBC dehydration in a transgenic mouse sickle cell disease model. It has been investigated for a number of possible uses, which include antimalarial activity, idiopathic pulmonary fibrosis, glioblastoma, lung cancer, non-alcoholic liver disease, hereditary xerocytosis, suppression of microglial activation in stroke, and immune system disorders.

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keySCTZUZTYRMOMKT-UHFFFAOYSA-N
InChI1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
SMILES stringO=C(N)C(C1=CC=C(F)C=C1)(C2=CC=C(F)C=C2)C3=CC=CC=C3
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number289656-45-7
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