DIASARONE-I

Code: SML2337-25MG D2-231

Biochem/physiol Actions

Diasarone-I is an antiviral agent isolated form Acorus tatarinowii Schott that potently inhibits dengue viral infection. Diasarone-I is binds...


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€336.50 25MG
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Biochem/physiol Actions

Diasarone-I is an antiviral agent isolated form Acorus tatarinowii Schott that potently inhibits dengue viral infection. Diasarone-I is binds to the viral 2′O methyltransferase of nonstructural protein 5 (NS5). It also decreases the DENV2-induced STAT1 phosphorylation and IFN-stimulated genes (ISGs) expression.

The antiviral effect of Diasarone-I includes half maximal effective concentration (EC50) of 4.5 μM and half maximal cytotoxicity concentration (CC50) of >80 μM.

assay≥98% (HPLC)
colorwhite to beige
formpowder
SMILES stringC/C(C(CC)C1=CC(OC)=C(OC)C=C1OC)=CC2=C(OC)C=C(OC)C(OC)=C2
solubilityDMSO: 2 mg/mL, clear
storage temp.−20°C
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