ITH12575

Code: SML1947-5MG D2-231

Biochem/physiol Actions

ITH12575 is apotent and selective inhibitor of mitochondrial Na+/Ca2+ exchanger mNCX with neuroprotective activity. It was shown to reduce Ca2+ efflux...


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€110.80 5MG
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Biochem/physiol Actions

ITH12575 is apotent and selective inhibitor of mitochondrial Na+/Ca2+ exchanger mNCX with neuroprotective activity. It was shown to reduce Ca2+ efflux from the mitochondria to the cytosol with an EC50 value of 690 nM and was shown to protect against Ca2+ overload and mitigated the neuronal damage in a model of oxidative stress. At higher concentrations ITH12575 also reduced Ca2+ influx through CALHM1, a Ca2+ channel that plays a key role in the neuronal electrical activity.

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
SMILES stringCC(C)C1=C(C2C(C=C(Cl)C=C3)=C3NC(CS2)=O)C=CC=C1
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number1802013-08-6
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