BZ-423

Code: SML1944-25MG D2-231

Application

Bz-423 has been used as a mitochondrial inner membrane pore (MIMP) reagent to study its effect on oxygen consumption rate (OCR) and ATP synthesis in HepG2 cells.<...


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€338.51 25MG
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Application

Bz-423 has been used as a mitochondrial inner membrane pore (MIMP) reagent to study its effect on oxygen consumption rate (OCR) and ATP synthesis in HepG2 cells.

Biochem/physiol Actions

Bz-423 stimulates mitochondrial inner membrane pore (MIMP) opening in isolated mitochondria.

Bz-423 is an inhibitor of mitochondrial F1F0 ATP synthase. It binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase, resulting in superoxide generation and apoptosis. BZ-423 was shown to block multidrug-resistant melanoma cells. In another study, Bz-423 selectively increased superoxide and induced the apoptosis of alloreactive T cells, which arrested established Graft versus Host Disease.

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyIJEUIRDNQUQMFU-UHFFFAOYSA-N
InChI1S/C27H21ClN2O2/c1-30-25-13-10-21(28)16-23(25)26(19-8-11-22(31)12-9-19)29-24(27(30)32)15-17-6-7-18-4-2-3-5-20(18)14-17/h2-14,16,24,29H,15H2,1H3
Quality Level100
SMILES stringClC1=CC=C2C(C(C3=CC=C(O)C=C3)=NC(CC4=CC=C(C=CC=C5)C5=C4)C(N2C)=O)=C1
solubilityDMSO: 2 mg/mL, clear
storage temp.2-8°C
Cas Number216691-95-1
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