GEFITINIB

Code: SML1657-50MG D2-231

Application

Gefitinib has been used : To study its effective use in endometrial cancer therapy Cell proliferation, cell cycle and apoptosis assays Cell viability assay and co...


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€522.77 50MG
€643.01 inc. VAT
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Application

Gefitinib has been used : To study its effective use in endometrial cancer therapy Cell proliferation, cell cycle and apoptosis assays Cell viability assay and colony formation assay

Biochem/physiol Actions

Gefitinib is a selective epidermal growth factor receptor tyrosine kinase (EGFR TK) inhibitor. Gefitinib has antineoplastic activity, and has been approved for the treatment on non-small cell lung cancer (NSCLC).Gefitinib has a higher affinity for ATP (adenosine triphosphate) binding site in the EGFR tyrosine kinase domain than ATP. Hence, gefitinib is known to inhibit the progression of endometrial cancer.

Packaging

10, 50 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Gene Informationhuman ... EGFR(1956)
InChI keyXGALLCVXEZPNRQ-UHFFFAOYSA-N
InChI1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
Quality Level100
SMILES stringCOC(C=C(N=CN=C1NC2=CC(Cl)=C(F)C=C2)C1=C3)=C3OCCCN4CCOCC4
solubilityDMSO: 10 mg/mL, clear
storage temp.room temp
Cas Number184475-35-2
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