Biochem/physiol Actions

Leucinostatins A and B are the major components of an atypical nonapeptide complex produced by Paecilomyces lilacinus. Leucinostatins display broad bio-activity against gram-positive bacteria, fungi, plants and tumor cell lines. They play a role as uncouplers in the inner mitochondria membrane and inhibit mitochondrial ATP synthesis. Recently, interest in Leucinostatins has focused on other aspects such as understanding their activity: insulin-like growth factor I regulators, ionophore, inhibitors of cell surface expression of viral glycoproteins and their potent in vitro and in vivo anti-trypanosomal activity.

Components

Mixture of Leucinostatin A (Cas# 76600-38-9 / MF: C₆₂H₁₁₁N₁₁O₁₃) and Leucinostatin B (Cas# 76663-52-0 / MF: C₆₁H₁₀₉N₁₁O₁₃).

Other Notes

Stable at −20 °C for at least 2 years.