HTH-01-015

Code: SML1446-25MG D2-231

Biochem/physiol Actions

HTH-01-015 is a potent and selective inhibitor of NUAK1 kinase, a member of the AMPK family that are that are activated by the LKB1 (liver kinaseB1) t...


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€423.40 25MG
€520.78 inc. VAT
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Biochem/physiol Actions

HTH-01-015 is a potent and selective inhibitor of NUAK1 kinase, a member of the AMPK family that are that are activated by the LKB1 (liver kinaseB1) tumour suppressor kinase and involved in development and proliferation. HTH-01-015 has an IC50 of 100 nM for NUAK1, >100-fold higher than NUAK2, and has no significant inhibition of 139 other kinases tested, including ten AMPK-related kinase family members. Treatment with HTH-01-015 was found to suppress proliferation, restricting cells from entering into mitosis.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to light brown
formpowder
InChI keyCHSDJDLAKKAWCI-UHFFFAOYSA-N
InChI1S/C26H28N8O/c1-16-23-24(31-26(29-16)30-19-14-28-34(15-19)20-8-10-27-11-9-20)32(2)22-13-18-7-5-4-6-17(18)12-21(22)25(35)33(23)3/h4-7,12-15,20,27H,8-11H2,1-3H3,(H,29,30,31)
Quality Level100
SMILES stringCC1=C2C(N(C)C(C=C(C=CC=C3)C3=C4)=C4C(N2C)=O)=NC(NC5=CN(C6CCNCC6)N=C5)=N1
solubilityDMSO: 5 mg/mL, clear (warmed)
storage temp.−20°C
Cas Number1613724-42-7
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