VU0453379 HYDROCHLORIDE

Code: SML1357-25MG D2-231

Biochem/physiol Actions

VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1) with GLP-1 EC50 = 1.3 µ...


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€551.80 25MG
€678.71 inc. VAT
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Biochem/physiol Actions

VU0453379 is a highly selective CNS penetrant positive allosteric modulator of Glucagon-like peptide-1 (GLP-1) with GLP-1 EC50 = 1.3 µ,M, 59.2% GLP-1 max. VU0453379 potentiated low-dose exenatide to augment insulin secretion in primary mouse pancreatic islets. In a model of Parkinson’;s disease it showed a significant reversal of haloperidol-induced catalepsy at 30 mg/kg.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyOCMGNMGYQPPMFF-FYZYNONXSA-N
InChI1S/C26H34N4O2.ClH/c1-17(2)29-14-8-11-19(29)15-27-25(31)21-16-30(18-9-4-5-10-18)26(32)24-23(21)20-12-6-7-13-22(20)28(24)3;/h6-7,12-13,16-19H,4-5,8-11,14-15H2,1-3H3,(H,27,31);1H/t19-;/m0./s1
Quality Level100
SMILES stringCN1C2=C(C(C(NC[C@@H]3CCCN3C(C)C)=O)=CN(C4CCCC4)C2=O)C5=CC=CC=C51.Cl
solubilityH2O: 20 mg/mL, clear
storage conditiondesiccated
storage temp.2-8°C
Cas Number1638646-27-1
This product has met the following criteria to qualify for the following awards:



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