API-1

Code: SML1342-5MG D2-231

Biochem/physiol Actions

API-1 is a potent and specific Akt/PKB inhibitor. API-1 binds to pleckstrin homology (PH) domain of Akt and blocks Akt membrane translocation. The com...


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€160.50 5MG
€197.42 inc. VAT
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Biochem/physiol Actions

API-1 is a potent and specific Akt/PKB inhibitor. API-1 binds to pleckstrin homology (PH) domain of Akt and blocks Akt membrane translocation. The compound inhibits all three members of the family Akt1/PKBa, Akt2/PKBb and Akt3/PKBg. API-1 does not inhibit the activation of PKC, SGK, PKA, STAT3, Erk-1/2 or JNK.

Packaging

5, 25 mg in glass bottle

assay≥95% (HPLC)
colorwhite to beige
formpowder
InChI keySPBWHPXCWJLQRU-FITJORAGSA-N
InChI1S/C13H15N5O6/c14-10-6-7(20)4(11(15)23)1-18(12(6)17-3-16-10)13-9(22)8(21)5(2-19)24-13/h1,3,5,8-9,13,19,21-22H,2H2,(H2,15,23)(H2,14,16,17)/t5-,8-,9-,13-/m1/s1
Quality Level100
SMILES stringO=C1C(C(N)=O)=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C3=C1C(N)=NC=N3
solubilityDMSO: 1 mg/mL, clear (warmed)
storage temp.−20°C
Cas Number36707-00-3
Hazard Class6.1
Un Number2811
Pack GroupIII
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