RA-9

Code: SML1206-25MG D2-231

Biochem/physiol Actions

RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 2...


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€461.70 25MG
€567.89 inc. VAT
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Biochem/physiol Actions

RA-9 is a cell permeable and potent inhibitor of the ubiquitin-proteasome system (UPS) that targets deubiquitinating enzymes (DUB) without affecting 20S proteasome catalytic-core activity. RA-9 directly inhibits activity of following DUB UCH-L1, UCH-L3, USP2, USP5 and USP8 deubiquitinating enzymes, which results in rapid accumulation of poly-ubiquitinated proteins leading to cell cycle checkpoint arrest and tumor cell apoptosis.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
InChI keyYUYPWAMLWZVHAE-KAVGSWPWSA-N
InChI1S/C19H15N3O5/c23-19-15(9-13-1-5-17(6-2-13)21(24)25)11-20-12-16(19)10-14-3-7-18(8-4-14)22(26)27/h1-10,20H,11-12H2/b15-9+,16-10+
Quality Level100
SMILES stringO=C(/C(CNC/1)=C/C2=CC=C([N+]([O-])=O)C=C2)C1=CC3=CC=C([N+]([O-])=O)C=C3
solubilityDMSO: 2 mg/mL, clear (warmed)
storage temp.2-8°C
Cas Number919091-63-7
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