Application

Spautin-1 has been used as an autophagy inhibitor:to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse modelto evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicinto study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay

Biochem/physiol Actions

Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines.

Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.

Packaging

5, 25 mg in glass bottle