Biochem/physiol Actions

CP724714 is a potent and selective inhibitor of HER2/ErbB2 with an IC₅₀ value of 10 nM. CP724714 is >640-fold selectivity against EGFR, and >1000-fold selective against InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met, JNK-2, JNK-3, ZAP-70, CDK-2 and CDK-5 in in vitro kinase assays. CP724714 had antiproliferative effects in a panel of human breast cancer cell lines.

Legal Information

Pfizer is a registered trademark of Pfizer, Inc.

Sold for research purposes under agreement from Pfizer Inc.

Other Notes

CP-724714 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the CP-724714 probe summary on the Chemical Probes Portal website.

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

Packaging

5, 25 mg in glass bottle