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Immunogen

The epitope recognized by PLA0243 maps to a region between residue 1401 and 1451 of human Fanconi anemia, complementation group D2 using the numbering given in entry NP_001018125.1 (GeneID 2177).

Other Notes

FANCD2 (Fanconi anemia, complementation group D) is a protein involved in DNA repair. Defects in FANCD2 are the cause of Fanconi anemia, a heterogenous autosomal recessive disorder characterized by congenital malformations and a predisposition to cancer. The FANCD2 gene is one of 13 complementation groups that include FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, and FANCN/PALB2. The FANC members are not homologous proteins but are related by their assembly into a common nuclear complex.

Physical form

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide