27-HYDROXYCHOLESTEROL (D6)

Code: LM4114-1EA D2-231

Application

27-hydroxycholesterol (D6) or cholest-5-ene-3β,27-diol(d6) has been used as an internal standard to measure the concentration of 27-hydroxycholesterol in the pre-...


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Application

27-hydroxycholesterol (D6) or cholest-5-ene-3β,27-diol(d6) has been used as an internal standard to measure the concentration of 27-hydroxycholesterol in the pre- and post-statin-treated serum samples by mass spectrometry.

Biochem/physiol Actions

27-hydroxycholesterol is known to induce breast cancer cell proliferation and metastatic progression in experimental models. It might serve as a ligand for liver X receptors (LXR) and farnesoid X-activated receptors (FXRs). 27-hydroxycholesterol controls the action of hydrocymethylglutaryl-CoA reductase. It promotes cholesterol efflux from the vascular endothelium.

General description

27-hydroxycholesterol is an abundant oxysterol in circulation.

Packaging

2 mL Amber Glass Sealed Ampule (LM4114-1EA)

application(s)lipidomicsmetabolomics
concentration~10 µg/mL (Refer to C of A for lot specific concentration. )
formmethanol solution
manufacturer/tradenameAvanti Polar Lipids LM4114
packagingpkg of 1 × 1 mL (LM4114-1EA)
shipped indry ice
SMILES string[H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC([2H])(C(O)([2H])[2H])C([2H])([2H])[2H]
storage temp.−20°C
Cas Number1246302-95-3
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