Application

Screening kit for CN (Buchwald-Hartwig) cross-coupling reaction. There are four possible screens that can be run based upon the user’;s substrates. Step-by-step user guides and a downloadable experimental excel sheets for each screen is provided in the below hyperlinks.Two Solvents, Weak Base (Cs₂CO₃)Two Solvents, Strong Base (NaOt-Bu)One Solvent (Dioxane), Two BasesOne Solvent (DMAc), Two BasesEach kit contains 4 screening sets that contain the following:Each customizable screening kit contains 12 X 2 pre-weighed catalysts (1 µmol) in individual microvials with magnetic stir bars 2 bases (NaOt-Bu and Cs₂CO₃) 2 degassed anhydrous solvents (dioxane and DMAc) in ampules 2 substrate reaction vials with stir bars 1 internal standard 4 reaction block replacement filmsthis protocolBest when used with KitAlysis Benchtop Inertion Box and 24-well Reaction Block (sold separately).

Features and Benefits

Designed and tested by synthetic chemists Easily run 24-microscale reaction in parallel 10 µmol reactions with 1 µmol catalyst, 3 equiv. base, 0.1 M concentration Customizable Excel Template for quick calculations and easy incorporation into electronic laboratory notebooks

Legal Information

KitAlysis is a trademark of Sigma-Aldrich Co. LLC