Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

Biochem/physiol Actions

RNA exonuclease 1 homolog (REXO1) plays a vital role in the regulation of proliferation or differentiation of adult stem cells (ASCs). Members of the YY1 sub-family of transcription factors including REX1, function as repressors and activators/transcription initiators. Presently, REXO1 is extensively used as a stem cell marker. In addition, this protein also blocks the signaling via the janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway during the differentiation of F9 teratocarcinoma stem cells.

Features and Benefits

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

General description

The RNA exonuclease 1 homolog (REXO1) gene, also known as zinc finger protein 42 (ZFP42), is mapped to human chromosome 19p13.3.The gene codes for an acidic zinc finger protein, which is a member of yin yang 1(YY1) sub-family of transcription factors. REXO1 is highly expressed in F9 teratocarcinoma stem cells, embryonic stem cells and other stem cells.

Immunogen

REX1, RNA exonuclease 1 homolog (S. cerevisiae) recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC

Linkage

Corresponding Antigen APREST82465.

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.