HPA019544-25UL Display Image


Code: HPA019544-25UL D2-231


All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the mos...

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All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Biochem/physiol Actions

AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2) is involved in enzymatic activity of phospholipid biosynthesis. It converts lysophosphatidic acid (LPA) to phosphatidic acid (PA) during biosynthesis of glycerophospholipids and triglycerides from glycerol-3-phosphate via catalytic acylation. It also plays a crucial role in regulating the cell proliferation and tumor growth of human osteosarcoma cells.In lipid biosynthesis, it helps to generate phosphatidic acid. Mutation in AGPAT2 causes a rare autosomal recessive disorder, congenital generalized lipodystrophy (CGL) with extreme reduction of white adipose tissue (WAT) mass.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.Every Prestige Antibody is tested in the following ways: IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues. Protein array of 364 human recombinant protein fragments.

General description

AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2) gene contains six exons, and is located to chromosome 9, region q34.3. It is a novel member of the acyltransferase enzyme family comprising of two conserved motifs, NHX(4)D and EGTR. It is highly expressed in liver, and pancreas. Its expression have also been found in placenta and brain subregions at low extent.


1-acyl-sn-glycerol-3-phosphate acyltransferase beta recombinant protein epitope signature tag (PrEST)

Legal Information

Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC


Corresponding Antigen APREST73053.

Physical form

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
enhanced validationrecombinant expressionLearn more about Antibody Enhanced Validation
formbuffered aqueous glycerol solution
Gene Informationhuman ... AGPAT2(10555)
packagingantibody small pack of 25 µL
product linePrestige Antibodies® Powered by Atlas Antibodies
Quality Level100
shipped inwet ice
species reactivityhuman
storage temp.−20°C
technique(s)western blot: 0.04-0.4 µg/mL, immunohistochemistry: 1:20-1:50
UniProt accession no.O15120
This product has met the following criteria: