Application

HA-1077 dihydrochloride has been used:to relax cantileversin the functional assessment of isolated coronary arteriesto investigate the effect of azaindole-1, fasudil on acute hypoxic pulmonary vasoconstriction (HPV)

Biochem/physiol Actions

Novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca²⁺ antagonist.

HA-1077/fasudil, is a Rho kinase inhibitor. This ROCK inhibitor has the ability to increase cognitive deficits in animals, that have Alzheimer′s disease (AD). In humans, fasudil possesses high therapeutic effects against cerebral vasospasm after subarachnoid hemorrhage (SAH). HA-1077 also acts as an inhibitor of protein kinases, like myosin light chain kinase and Rho associated kinase. Hence, it can block myosin phosphorylation.

Packaging

5, 10 mg in glass bottle