Doxepin hydrochloride Z-isomer basis E-isomer basis, approx.85% E-isomer basis, >=98% (GC), 15% Z-isomer basis, powder

Code: D4526-1G D2-231

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of norepinephrine uptake than of serotonin uptake; antagonist at H1 histamine, mus...


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Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of norepinephrine uptake than of serotonin uptake; antagonist at H1 histamine, muscarinic cholinergic, and α-adrenoreceptors.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Doxepin is used to treat chronic idiopathic urticaria, chronic pain and anxiety. Doxepin exhibits antiserotonergic properties.

Other Notes

Mixture of cis- and trans-isomers

Packaging

1, 5 g in glass bottle

assay15% Z-isomer basis, ~85% E-isomer basis, ≥98% (GC)
colorwhite to off-white
formpowder
Gene Informationhuman ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), HRH1(3269), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
InChI keyMHNSPTUQQIYJOT-SJDTYFKWSA-N
InChI1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11+;
originatorBoehringer Ingelheim
Quality Level200
SMILES stringCl[H].CN(C)CCC=C1/c2ccccc2COc3ccccc13
solubility1 M HCl: 50 mg/mL, H2O: soluble
Cas Number1229-29-4
Hazard Class6.1
Un Number2811
Pack GroupIII
This product has met the following criteria to qualify for the following awards:



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