Application

After being activated with silicophilic activators, like fluorides, alkoxides or carboxylates, phenylsulfanyltetrafluoroethyl trimethylsilane acts as nucleophilic phenylsulfanyltetrafluoroethylation reagent towards electrophiles such as aromatic aldehydes. A phenylsulfanyltetrafluoroethyl moiety incorporated in the substrate can be treated with tributyltin hydride and generate the corresponding fluoroalkyl radical. If the substrate lacks any olefins, it can be reduced to tetrafluoroethyl group whereas if the substrate contains an olefin in the correct spatial orientation, it can lead to an intramolecular cyclization affording tetrafluorinated cyclic structures.

Legal Information

Product of CF Plus Chemicals.

Other Notes

Technology Spotlight: Fluoroalkylation: Expansion of Togni Reagents