CI-1033, >=98% (HPLC)

Code: C7249-5MG D2-231

Biochem/physiol Actions

CI-1033 is a potent, irreversible ATP binding site–directed pan-ErbB tyrosine kinase inhibitor with IC50 in the low nanomolar range f...


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€93.50 5MG
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Biochem/physiol Actions

CI-1033 is a potent, irreversible ATP binding site–directed pan-ErbB tyrosine kinase inhibitor with IC50 in the low nanomolar range for EGFR, HER2, and ErbB-4.

Features and Benefits

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This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
formsolid
Gene Informationhuman ... EGFR(1956), ERBB2(2064), ERBB4(2066)
InChI keyJZZFDCXSFTVOJY-UHFFFAOYSA-N
InChI1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);2*1H
Quality Level100
SMILES stringCl.Cl.Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
solubilityH2O: >10 mg/mL, DMSO: >10 mg/mL
storage temp.−20°C
Cas Number289499-45-2
This product has met the following criteria to qualify for the following awards:



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