Cortisol-D4 (9,11,12, 12-D4) solution, 100 mug/mL in methanol, ampule of 1 mL, certified reference material

Code: C-113-1ML D2-231

Application

This Certified Spiking Solution® is suitable for GC/MS and LC/MS applications from clinical and diagnostic testing and endocrinology to sports tes...


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€477.90 1ML
€587.82 inc. VAT
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Application

This Certified Spiking Solution® is suitable for GC/MS and LC/MS applications from clinical and diagnostic testing and endocrinology to sports testing.The Certified Reference Material (CRM) in solution can also be used as an internal standard as follows:•Identification of cortisol by atmospheric pressure chemical ionization (APCI) and selected reaction monitoring (SRM) during the high-performance liquid chromatography- tandem mass spectrometric (HPLC-MS/MS) analysis of cortisol in human sweat samples•Combined determination of cortisol and cortisone in 48 serum samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS)•Development and validation of an LC-MS/MS method to determine five steroids― free cortisol, cortisone, tetrahydrocortisol, allo-tetrahydrocortisol, and tetrahydrocortisone in urine samples•Multi-residue analysis of cortisol, cortisone, and dehydroepiandrosterone sulfate (DHEAS) in 103 hair samples by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-MS/MS)•Rapid LC-MS/MS-based assay of cortisol in 2860 serum samples over a duration of one year, using a simple protein precipitation technique for sample preparation

Features and Benefits

Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability Rigorously tested through real-time stability studies to ensure accuracy and shelf life Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty Flame sealed under argon into ampoules for long-term shelf life Offered in a convenient, DEA-exempt format to improve laboratory efficiency

General description

Cortisol-D4 (9,11,12, 12-D4) is the deuterated form of the glucocorticoid, cortisol. This stable labeled internal standard is suitable for quantitation of cortisol levels in whole blood by LC-MS/MS for newborn screening of congenital adrenal hyperplasia (CAH) and in serum or plasma by LC-MS/MS for determination of several diseases including Cushing's syndrome, Addison's disease, and Sheehan's syndrome.

Legal Information

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

CERILLIANT is a registered trademark of Cerilliant Corporation

application(s)clinical testingclinical testing
concentration100 µg/mL in methanol
featureSnap-N-Spike®/Snap-N-Shoot®
formliquid
formatsingle component solution
gradecertified reference material
InChI keyJYGXADMDTFJGBT-BJJKTIQHSA-N
InChI1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1/i10D2,16D,18D
manufacturer/tradenameCerilliant®
packagingampule of 1 mL
Quality Level300
SMILES string[2H]C1([2H])[C@]([2H])(O)[C@@]2([2H])[C@@H](CCC3=CC(=O)CC[C@]23C)[C@@H]4CCC(O)(C(=O)CO)[C@@]14C
storage temp.−20°C
technique(s)gas chromatography (GC): suitable, liquid chromatography (LC): suitable
Cas Number73565-87-4
Hazard Class3
Un Number1230
Pack GroupII
This product has met the following criteria to qualify for the following awards:



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