Anti-Lysyl Oxidase (LOX)

Application

Anti-Lysyl Oxidase (LOX) Antibody is an antibody against Lysyl Oxidase (LOX) for use in Western Blotting, IHC(P).

Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Lysyl Oxidase (LOX) in adenocarcinoma cells of human prostate tissues.

General description

Lysyl Oxidase (Protein-lysine 6-oxidase; LOX) is a member of the lysyl oxidase family and a product of the LOX gene. Lysyl oxidase is an extracellular-matrix oxidative enzyme characterized by its C-terminal LOX catalytic domain. In the presence of copper, lysyl oxidase removes amine groups from lysine residues of target substrates which include precursors of collagen and elastin. This deamination reaction produces reactive lysine residues which can then interact with similarly activated species to form covalent cross-links. Lysyl oxidase is found predominantly in the kidney, pancreas, heart, skeletal muscle, and placenta. Defective lysyl oxidase proteins play a role in cutis laxa autosomal recessive type 1 condition. Other studies have also suggested that lysyl oxidase may also be involved in intracellular signaling and may function as a tumor suppressor.

Immunogen

KLH-conjugated linear peptide corresponding to Lysyl Oxidase (LOX).

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Quality

Evaluated by Western Blot in NIH/3T3 nuclear extract.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected Lysyl Oxidase (LOX) in 10 µg of NIH/3T3 nuclear extract.

Target description

~46 kDa observed