4-(1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-Y+

Code: 916870-100MG D2-231

Application

4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein ...


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Application

4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationCrosslinkers for BioconjugationPortal: Building PROTAC® Degraders for Targeted Protein Degradation

assay≥95%
formpowder
Quality Level100
SMILES stringO=C(N(CC1)CCC1C(C=C2)=CC=C2C(O)=O)OC(C)(C)C
storage temp.2-8°C
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