Application

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Other Notes

Recruiting cytotoxic T cells to folate-receptor-positive cancer cellsSyntheses and characterizations of novel pyrrolocoumarin probes for SNAP-tag labeling technologyHigh density orthogonal surface immobilization via photoactivated copper-free click chemistry