(4-HYDROXYPHENYL)(4-(PROP-2-YN-1-YLOXY)

Application

(4-Hydroxyphenyl)(4-(prop-2-yn-1-yloxy)phenyl)methanone is used for chemical probe synthesis, this trifunctional building block contains a light-activated benzophenone, alkyne tag, and hydroxyl synthetic handle. When appended to a ligand or pharmacophore through its hydroxyl linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

Technology Spotlight: Trifuctional Probe Building BlocksA library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpSDesign, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoidsClickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 5 Based on Select Acetylenic Negative Allosteric Modulatorsγ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin

Packaging

100 mg in glass bottle