12:0(2S-OH) CERAMIDE

Biochem/physiol Actions

Hydroxy fatty acid (hFA)-sphingolipids facilitate cell signaling. hFA-ceramides contribute to the permeability barrier function of the epidermis. Synthesis of hFA-ceramides are catalyzed by fatty acid 2-hydroxylase (FA2H). Mutations of FA2H causes nervous system disorders leukodystrophy and spastic paraparesis in humans. Anantitumor drug, PM02734 requires hFA-ceramides in the cell membrane to exhibit its activity.

General description

Ceramides with 2-hydroxy fatty acids (hFA) group are present in the epidermis. 12:0(2S-OH) Ceramide is a 2S hydroxylated lauric acid-containing ceramide.

Packaging

5 mL Amber Glass Screw Cap Vial (860812P-5mg)