C16 GALACTOSYL( BETA) CERAMIDE (D18:1/1

Application

C16 Galactosyl(β) ceramide (d18:1/16:0) has been used as a lipid standard for its quantification using differential ion mobility spectrometry (DMS) coupled with liquid chromatography in electrospray ionization tandem mass spectrometry (LC-ESI-DMS-MS/MS) in human plasma. It has also been used for the preparation of lipid dispersions. It may be used as a glycosphingolipid (GSL) standard to optimize its characteristic fragmentation using electrospray ionization (ESI) triple quadrupole tandem mass spectrometry (MS/MS). It may also be used to study the structural changes caused by ultraviolet (UVA)?induced photooxidation of galactosyl (GalCer) by electrospray ionization mass spectrometry (ESI?MS) analysis.

Biochem/physiol Actions

Galactosyl ceramide is crucial for normal myelin function andstability.It prevents epithelial cell-human immunodeficiency virus 1 (HIV-1) virion binding.

General description

D-galactosyl-β-1,1′N-palmitoyl-D-erythro-sphingosine or C16 Galactosyl(β) ceramide consists of a cer(d18:1/16:0) core structure to which a sugar molecule and galactose, is linked through β-glycosidic linkage. Galactosyl ceramide is a complex glycosphingolipid, which contains a single galactose residue linked toceramide. It is a major constituent of the myelinsheath. Galactosyl ceramide is found majorly on the surface of colonic epithelial cells, vaginal epithelium and primary mammary epithelial cells.

Packaging

5 mL Amber Glass Screw Cap Vial (860521P-5mg)