16:0-06:0 NBD PA

Application

16:0-06:0 NBD PA 1-palmitoyl-2-{6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl}-sn-glycero-3-phosphate is suitable to measure the substrate transport by an increase in cellular fluorescence to determine type 4 P-type ATPases (P4-ATPase) discrimination and its glycerophospholipid (GPL) substrate selection through the directed evolution of a sphingomyelin (SM) flippase.

Biochem/physiol Actions

Phosphatidic acid (PA) is crucial for intracellular signaling involved various cellular processes including membrane trafficking and sperm hyper-activation. It plays a vital role in lipid synthesis.

General description

Phosphatidic acid (PA) is a simple anionic membrane phospholipid. The phospholipid contains phosphomonoester polar head group and two long hydrophobic acyl chains. 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) PA is a fluorescent analog with 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) attached to the sn-2 fatty acid of PA.

Packaging

5 mL Amber Glass Screw Cap Vial (810173P-1mg)